Journal
ANNUAL REVIEW OF BIOPHYSICS, VOL 39
Volume 39, Issue -, Pages 265-289Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.biophys.093008.131228
Keywords
Dictyostelium; adaptation; Local Excitation Global Inhibition (LEGI) model; protein localization
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM028007, R01GM034933, T32GM007445, R37GM028007] Funding Source: NIH RePORTER
- NIGMS NIH HHS [T32 GM007445, GM34933, GM28007, R01 GM028007, R01 GM034933, R37 GM028007] Funding Source: Medline
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Chemotaxis, the directed migration of cells in chemical gradients, is a vital process in normal physiology and in the pathogenesis of many diseases. Chemotactic cells display motility, directional sensing, and polarity. Motility refers to the random extension of pseudopodia, which may be driven by spontaneous actin waves that propagate through the cytoskeleton. Directional sensing is mediated by a system that detects temporal and spatial stimuli and biases motility toward the gradient. Polarity gives cells morphologically and functionally distinct leading and lagging edges by relocating proteins or their activities selectively to the poles. By exploiting the genetic advantages of Dictyostelium, investigators are working out the complex network of interactions between the proteins that have been implicated in the chemotactic processes of motility, directional sensing, and polarity.
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