Journal
JOURNAL OF BACTERIOLOGY
Volume 187, Issue 23, Pages 8196-8200Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.187.23.8196-8200.2005
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Bacterial histidine kinases have been proposed as targets for the discovery of new antibiotics, yet few specific inhibitors of bacterial histidine kinases have been reported. We report here a novel thienopyridine (TEP) compound that inhibits bacterial histidine kinases competitively with respect to ATP but does not comparably inhibit mammalian serine/threonine kinases. Although it partitions into membranes and does not inhibit the growth of bacterial or mammalian cells, TEP could serve as a starting compound for a new class of histidine kinase inhibitors with antibacterial activity.
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