Journal
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 16
Volume 16, Issue -, Pages 53-76Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-bioeng-071813-104517
Keywords
heart valve; finite element analysis; cardiac imaging; aortic valve; mitral valve
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Funding
- NHLBI NIH HHS [R01 HL104080, R21 HL108239, R21 HL108240] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL104080, R21HL108240, R21HL108239] Funding Source: NIH RePORTER
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In the past two decades, major advances have been made in the clinical evaluation and treatment of valvular heart disease owing to the advent of noninvasive cardiac imaging modalities. In clinical practice, valvular disease evaluation is typically performed on two-dimensional (2D) images, even though most imaging modalities offer three-dimensional (3D) volumetric, time-resolved data. Such 3D data offer researchers the possibility to reconstruct the 3Dgeometry of heart valves at a patient-specific level. When these data are integrated with computational models, native heart valve biomechanical function can be investigated, and preoperative planning tools can be developed. In this review, we outline the advances in valve geometry reconstruction, tissue property modeling, and loading and boundary definitions for the purpose of realistic computational structural analysis of cardiac valve function and intervention.
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