Journal
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 15
Volume 15, Issue -, Pages 177-200Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-bioeng-071812-152428
Keywords
regenerative medicine; microvascularization; angiogenesis; lymphangiogenesis
Categories
Funding
- Canadian Institutes of Health Research [MOP-106700] Funding Source: Medline
Ask authors/readers for more resources
Vascularization is one of the great challenges that tissue engineering faces in order to achieve sizeable tissue and organ substitutes that contain living cells. There are instances, such as skin replacement, in which a tissue-engineered substitute does not absolutely need a preexisting vascularization. However, tissue or organ substitutes in which any dimension, such as thickness, exceeds 400 mu m need to be vascularized to ensure cellular survival. Consistent with the wide spectrum of approaches to tissue engineering itself, which vary from acellular synthetic biomaterials to purely biological living constructs, approaches to tissue-engineered vascularization cover numerous techniques. Those techniques range from micropatterns engineered in biomaterials to microvascular networks created by endothelial cells. In this review, we strive to provide a critical overview of the elements that must be considered in the pursuit of this goal and the major approaches that are investigated in hopes of achieving it.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available