Journal
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 14
Volume 14, Issue -, Pages 129-154Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-bioeng-071811-150043
Keywords
branching morphogenesis; tension; mechanotransduction; patterning; morphogen; gradient
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Funding
- NCI NIH HHS [CA128660] Funding Source: Medline
- NHLBI NIH HHS [HL110335] Funding Source: Medline
- NIGMS NIH HHS [GM083997] Funding Source: Medline
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The ramified architectures of organs such as the mammary gland and lung are generated via branching morphogenesis, a developmental process through which individual cells bud and pinch off of pre-existing epithelial sheets. Although specified by signaling programs, organ development requires integration of all aspects of the microenvironment. We describe the essential role of endogenous cellular contractility in the formation of branching tubes. We also highlight the role of exogenous forces in normal and aberrant branching.
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