Journal
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 13
Volume 13, Issue -, Pages 245-267Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-bioeng-071910-124701
Keywords
stem cells; tissue engineering; heart regeneration; bioreactor; clinical translation
Categories
Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL076485, U01HL100408, R21HL108668] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [P41EB002520] Funding Source: NIH RePORTER
- NHLBI NIH HHS [U01 HL100408, R21 HL108668, R01 HL076485] Funding Source: Medline
- NIBIB NIH HHS [P41 EB002520] Funding Source: Medline
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The idea of extending the lifetime of our organs is as old as humankind, fueled by major advances in organ transplantation, novel drugs, and medical devices. However, true regeneration of human tissue has become increasingly plausible only in recent years. The human heart has always been a focus of such efforts, given its notorious inability to repair itself following injury or disease. We discuss here the emerging bioengineering approaches to regeneration of heart muscle as a paradigm for regenerative medicine. Our focus is on biologically inspired strategies for heart regeneration, knowledge gained thus far about how to make a perfect heart graft, and the challenges that remain to be addressed for tissue-engineered heart regeneration to become a clinical reality. We emphasize the need for interdisciplinary research and training, as recent progress in the field is largely being made at the interfaces between cardiology, stem cell science, and bioengineering.
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