Journal
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 13
Volume 13, Issue -, Pages 531-552Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-bioeng-071910-124717
Keywords
nano-CT; mini-CT; ex vivo; in vivo; X-ray phase; X-ray fluorescence
Categories
Funding
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB000305] Funding Source: NIH RePORTER
- NIBIB NIH HHS [EB000305, R01 EB000305] Funding Source: Medline
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Use of microscopic computed-tomography (micro-CT) scanning continues to grow in biomedical research. Laboratory-based micro-CT scanners, laboratory-based nano-CT scanners, and integrated micro-CT/SPECT and micro-CT/PET scanners are now manufactured for turn-key operation by a number of commercial vendors. In recent years a number of technical developments in X-ray sources and X-ray imaging arrays have broadened the utility of micro-CT. Of particular interest are photon-counting and energy-resolving detector arrays. These are being explored to maximize micro-CT image grayscale dynamic range and to further increase image contrast by utilizing the unique spectral attenuation characteristics of individual chemical elements. X-ray phase-shift images may increase contrast resolution and reduce radiation exposure. Although radiation exposure is becoming a concern with the drive for increased spatial and temporal resolution, especially for longitudinal studies, gated scans and limited scan-data-set reconstruction algorithms show great potential for keeping radiation exposure to a minimum.
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