Journal
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 12
Volume 12, Issue -, Pages 203-231Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-bioeng-070909-105351
Keywords
axon; neuron; contact guidance; cell tension; lithography
Categories
Funding
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB005722] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS044409, R01NS065109] Funding Source: NIH RePORTER
- NIBIB NIH HHS [R01 EB005722, R01 EB005722-01A2, EB005722] Funding Source: Medline
- NINDS NIH HHS [NS44409, NS65109, R01 NS044409, R01 NS065109] Funding Source: Medline
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In the body, cells encounter a complex milieu of signals, including topographical cues, in the form of the physical features of their surrounding environment. Imposed topography can affect cells on surfaces by promoting adhesion, spreading, alignment, morphological changes, and changes in gene expression. Neural response to topography is complex, and it depends on the dimensions and shapes of physical features. Looking toward repair of nerve injuries, strategies are being explored to engineer guidance conduits with precise surface topographies. How neurons and other cell types sense and interpret topography remains to be fully elucidated. Studies reviewed here include those of topography on cellular organization and function as well as potential cellular mechanisms of response.
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