Journal
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 12
Volume 12, Issue -, Pages 345-367Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-bioeng-070909-105339
Keywords
rheology; deformability; red blood cells; shear stress; viscosity; hemoglobin
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Funding
- NHLBI NIH HHS [R01 HL070047] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL070047] Funding Source: NIH RePORTER
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As the predominant cell type in blood, red blood cells (RBCs) and their biomechanical properties largely determine the rheological and hemodynamic behavior of blood in normal and disease states. In sickle cell disease (SCD), mechanically fragile, poorly deformable RBCs contribute to impaired blood flow and other pathophysiological aspects of the disease. The major underlying cause of this altered blood rheology and hemodynamics is hemoglobin S (HbS) polymerization and RBC sickling under deoxygenated conditions. This review discusses the characterization of the biomechanical properties of sickle RBCs and sickle blood as well as their implications toward a better understanding of the pathophysiology of the disease.
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