Journal
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 12
Volume 12, Issue -, Pages 143-166Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-bioeng-070909-105343
Keywords
genome; phenotype; mouse MRI
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Funding
- Canadian Institutes of Health Research Funding Source: Medline
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The completed sequencing of genomes has forced upon us the challenge of understanding how the detailed information in the genome gives rise to the specific characteristics-phenotype-of the individual. This is crucial for understanding not only normal development but also, from a medical perspective, the genetic basis of disease. Much of the mammalian genome-to-phenotype relationship will be worked out in the mouse, for which powerful genetic-manipulation tools are available. Mouse imaging combined with powerful statistical methods has a unique and growing role to play in phenotyping genetically modified mice. This review outlines the challenges for image-based phenotyping, summarizes the current state of three-dimensional imaging technologies for the mouse, and highlights new opportunities in systems biology that are opened by imaging mice.
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