Journal
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 83
Volume 83, Issue -, Pages 441-466Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-060713-035524
Keywords
RNA flexibility; riboswitches; regulatory RNA; molecular adaptation; RNA catalysis
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Funding
- NCRR NIH HHS [P41 RR012255, RR012255] Funding Source: Medline
- NIAID NIH HHS [R01 AI066975, R21 AI096985] Funding Source: Medline
- NIGMS NIH HHS [P01GM0066275, R01 GM089846, R01GM089846, R21GM096156, R21 GM096156, P01 GM066275] Funding Source: Medline
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RNA dynamics play a fundamental role in many cellular functions. However, there is no general framework to describe these complex processes, which typically consist of many structural maneuvers that occur over timescales ranging from picoseconds to seconds. Here, we classify RNA dynamics into distinct modes representing transitions between basins on a hierarchical free-energy landscape. These transitions include large-scale secondary-structural transitions at >0.1-s timescales, base-pair/tertiary dynamics atmicrosecond-to-millisecond timescales, stacking dynamics at timescales ranging from nanoseconds to microseconds, and other jittering motions at timescales ranging from picoseconds to nanoseconds. We review various modes within these three different tiers, the different mechanisms by which they are used to regulate function, and how they can be coupled together to achieve greater functional complexity.
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