Journal
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81
Volume 81, Issue -, Pages 203-229Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-060310-170328
Keywords
ubiquitin chain; linkage specificity
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Funding
- Medical Research Council [MC_U105192732] Funding Source: Medline
- MRC [MC_U105192732] Funding Source: UKRI
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The posttranslational modification with ubiquitin, a process referred to as ubiquitylation, controls almost every process in cells. Ubiquitin can be attached to substrate proteins as a single moiety or in the form of polymeric chains in which successive ubiquitin molecules are connected through specific isopeptide bonds. Reminiscent of a code, the various ubiquitin modifications adopt distinct conformations and lead to different outcomes in cells. Here, we discuss the structure, assembly, and function of this ubiquitin code.
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