Journal
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81
Volume 81, Issue -, Pages 119-143Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-052610-095910
Keywords
P-TEFb; NELF; DSIF; SEC; 7SK snRNP
Categories
Funding
- NIAID NIH HHS [AI095057, AI074392, R21 AI074392, R01 AI041757, AI41757, R33 AI074392] Funding Source: Medline
- NIGMS NIH HHS [R01 GM035500, GM35500] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI095057, R01AI041757, R33AI074392, R21AI074392] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM035500] Funding Source: NIH RePORTER
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Regulation of the elongation phase of transcription by RNA polymerase II (Pol II) is utilized extensively to generate the pattern of mRNAs needed to specify cell types and to respond to environmental changes. After Pol II initiates, negative elongation factors cause it to pause in a promoter proximal position. These polymerases are poised to respond to the positive transcription elongation factor P-TEFb, and then enter productive elongation only under the appropriate set of signals to generate full-length properly processed mRNAs. Recent global analyses of Pol II and elongation factors, mechanisms that regulate P-TEFb involving the 7SK small nuclear ribonucleoprotein (snRNP), factors that control both the negative and positive elongation properties of Pol II, and the mRNA processing events that are coupled with elongation are discussed.
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