Journal
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81
Volume 81, Issue -, Pages 661-686Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-060910-094416
Keywords
clathrin; dynamin; membrane; pinocytosis; filaments; Arp2/3
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM038542, F32GM083538, R01GM086882] Funding Source: NIH RePORTER
- NIGMS NIH HHS [F32 GM083538, R01 GM 38542, R01 GM086882, R01 GM038542] Funding Source: Medline
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Endocytosis includes a number of processes by which cells internalize segments of their plasma membrane, enclosing a wide variety of material from outside the cell. Endocytosis can contribute to uptake of nutrients, regulation of signaling molecules, control of osmotic pressure, and function of synapses. The actin cytoskeleton plays an essential role in several of these processes. Actin assembly can create protrusions that encompass extracellular materials. Actin can also support the processes of invagination of a membrane segment into the cytoplasm, elongation of the invagination, scission of the new vesicle from the plasma membrane, and movement of the vesicle away from the membrane. We briefly discuss various types of endocytosis, including phagocytosis, macropinocytosis, and clathrin-independent endocytosis. We focus mainly on new findings on the relative importance of actin in clathrin-mediated endocytosis (CME) in yeast versus mammalian cells.
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