Journal
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 68, Issue 1-2, Pages 15-26Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jri.2005.05.003
Keywords
peripheral T lymphocytes; placental micro-particles; pre-eclampsia
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Recent studies have suggested that pre-eclampsia may result from endothelial cell damage and overt immune activity triggered by the elevated release of syncytiotrophoblast-derived micro-particles (STBM). In this context, STBM have been reported to inhibit lymphocyte proliferation and induce Jurkat T cell apoptosis. In this study, STBM were prepared by three different in vitro methods (mechanical dissection, villous explant culture, and placental perfusion) and their functional properties were tested on T lymphocytes enriched from peripheral blood samples. Mechanically- and villous explant-derived STBM significantly inhibited activation, proliferation and cytokine release by T lymphocytes, while placental perfusion-derived STBM significantly induced T cell proliferation and a slight increase in IFN gamma release. None of the STBM preparations caused T cell apoptosis. Therefore, STBM prepared by different methods in vitro exhibit different effects on circulating T cells, a feature that will have to be taken into account when considering their potential role in normal pregnancy and pre-eclampsia. (C) 2005 Elsevier Ireland Ltd. All rights reserved.
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