Journal
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 80
Volume 80, Issue -, Pages 943-971Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-062708-134043
Keywords
GTP binding domain; three-dimensional structure; molecular switch
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GTP-binding (G) proteins constitute a class of P-loop (phosphate-binding loop) proteins that work as molecular switches between the GDP-bound OFF and the GTP-bound ON state. The common principle is the 160-180-residue G domain with an alpha,beta topology that is responsible for nucleotide-dependent conformational changes and drives many biological functions. Although the G domain uses a universally conserved switching mechanism, its structure, function, and GTPase reaction are modified for many different pathways and processes.
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