Journal
INTERNATIONAL JOURNAL OF TOXICOLOGY
Volume 35, Issue 1, Pages 27-37Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1091581815598749
Keywords
multiwall carbon nanotubes (MWCNTs); peripheral blood lymphocytes; cell growth; DNA damage; cytotoxicity; reactive oxygen species (ROS)
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Funding
- Industrial Strategic technology development program - Ministry of Trade, industry & Energy (MI, Korea) [10047829]
- Korea Evaluation Institute of Industrial Technology (KEIT) [10047829] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Carbon nanotubes (CNTs) have been introduced recently as a novel carrier system for both small and large therapeutic molecules. Biotin-functionalized single-wall CNTs have been conjugated with the anticancer agent taxoid using a cleavable linker, and multiwall carbon nanotubes (MWCNTs) conjugated with iron nanoparticles have been efficiently loaded with doxorubicin.(1,2) The MWCNTs are effective transporters for biological macromolecules and drugs to target cells and tissues, thereby attracting the attention of the biomedical industry.(3-7) Administrating MWCNTs for medical application invariably involves intravenous administration and ultimate contact with human peripheral blood lymphocytes (HPBLs), yet toxicological studies on the effect of MWCNTs on HPBLs are lacking. Accordingly, this study evaluated the cytotoxic and genotoxic effects of MWCNTs on healthy male HPBLs. Healthy male HPBLs were treated with MWCNTs at 3 different concentrations (12.5, 25, and 50 g/mL) for 48 hours. Under these conditions, the MWCNTs induced significant cell growth retardation, DNA damage, and cytotoxicity. The MWCNT-treated HPBLs also exhibited an increased intracellular reactive oxygen species level during the experimental period, which leads to cell damage and death, proliferation inhibition, DNA damage, and an inflammatory response.
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