Journal
JOURNAL OF VIROLOGY
Volume 79, Issue 23, Pages 14992-14997Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.79.23.14992-14997.2005
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Funding
- NHLBI NIH HHS [N01 HV028184] Funding Source: Medline
- NIAID NIH HHS [AI053785, R21 AI053785] Funding Source: Medline
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Lung cytokine and chemokine production by BALB/c mice infected with human metapneumovirus (hMPV) was compared to respiratory syncytial virus (RSV)-infected mice. hMPV infection induced lower levels of the inflammatory cytokines interleukin-1 (IL-1), IL-6 and tumor necrosis factor alpha but was a more potent inducer of granulocyte-macrophage colony-stimulating factor and triggered a more sustained production of the CXC chemokine KC compared to RSV. hMPV was a stronger inducer of both alpha interferon (IFN-alpha) and IFN-gamma responses than RSV. In regard to immunomodulatory cytokines, hMPV failed to induce detectable IL-10 or IL-12p70 but was a potent inducer of IL-12 p40 subunit. The implications for hMPV pathogenesis are discussed.
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