Journal
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 80
Volume 80, Issue -, Pages 885-916Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-081308-165917
Keywords
hormones; endocrine signaling; life span; aging; reproduction; diapause
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM008231] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG027498] Funding Source: NIH RePORTER
- NIA NIH HHS [R01 AG027498] Funding Source: Medline
- NIGMS NIH HHS [T32 GM008231] Funding Source: Medline
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Sterol metabolites are critical signaling molecules that regulate metabolism, development, and homeostasis. Oxysterols, bile acids (BAs), and steroids work primarily through cognate sterol-responsive nuclear hormone receptors to control these processes through feed-forward and feedback mechanisms. These signaling pathways are conserved from simple invertebrates to mammals. Indeed, results from various model organisms have yielded fundamental insights into cholesterol and BA homeostasis, lipid and glucose metabolism, protective mechanisms, tissue differentiation, development, reproduction, and even aging. Here, we review how sterols act through evolutionarily ancient mechanisms to control these processes.
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