Journal
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 80
Volume 80, Issue -, Pages 211-237Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-091008-152423
Keywords
signal transduction; allostery; transmembrane signaling; receptor; ion channel
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Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U01AI074571] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R37GM054616, R01GM056423, R01GM054616, F32GM084631] Funding Source: NIH RePORTER
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Signal transduction across biological membranes is central to life. This process generally happens through communication between different domains and hierarchical coupling of information. Here, we review structural and thermodynamic principles behind transmembrane (TM) signal transduction and discuss common themes. Communication between signaling domains can be understood in terms of thermodynamic and kinetic principles, and complex signaling patterns can arise from simple wiring of thermodynamically coupled domains. We relate this to functions of several signal transduction systems: the M2 proton channel from influenza A virus, potassium channels, integrin receptors, and bacterial kinases. We also discuss key features in the structural rearrangements responsible for signal transduction in these systems.
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