Journal
ANNUAL REVIEW OF BIOCHEMISTRY
Volume 78, Issue -, Pages 305-334Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.biochem.78.070507.135656
Keywords
aptamer; binding pocket; expression platform; ribozyme
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Funding
- NIH
- Howard Hughes Medical Institute.
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM068819] Funding Source: NIH RePORTER
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The cellular concentrations of certain metabolites are assiduously monitored to achieve appropriate levels of gene expression. Although proteins have long been known to act as sensors in this capacity, metabolite-binding RNAs, or riboswitches, also play an important role. More than 20 distinct classes of riboswitches have been identified to date, and insights to the molecular recognition strategies of a significant subset of these have been provided by detailed structural studies. This diverse set of metabolite-sensing RNAs is found to exploit a variety of distinct mechanisms to regulate genes that are fundamental to metabolism.
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