Journal
ANNUAL REVIEW OF BIOCHEMISTRY
Volume 78, Issue -, Pages 65-94Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.biochem.78.091707.100215
Keywords
antibiotic; bialaphos; fosfomycin; fosmidomycin; FR-900098; phosphinothricin; phosphonates
Categories
Funding
- National Institutes of Health [GM POI GM077596]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P01GM077596, R01GM059334] Funding Source: NIH RePORTER
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Natural products containing carbon-phosphorus bonds (phosphonic and phosphinic acids) have found widespread use in medicine and agriculture. Recent years have seen a renewed interest in the biochemistry and biology of these compounds with the cloning of the biosynthetic gene clusters for several family members. This review discusses the commonalities and differences in the molecular logic that lie behind the biosynthesis of these compounds. The current knowledge regarding the metabolic pathways and enzymes involved in the production of a number of natural products, including the approved antibiotic fomycin, the widely used herbicide phosphinothricin (PT), and the clinical candidate for treatment of malaria FR-900098, is presented. Many of the enzymes involved in the biosynthesis of these compounds catalyze chemically and biologically unprecedented transformations, and a wealth of new biochemistry has been revealed through their study. These investigations have also suggested new strategies for natural product discovery.
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