Journal
ANNUAL REVIEW OF BIOCHEMISTRY
Volume 77, Issue -, Pages 383-414Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.biochem.75.101304.124125
Keywords
affinity label; mass spectrometry; proteomics
Categories
Funding
- NATIONAL CANCER INSTITUTE [R33CA118696, R01CA087660, R37CA087660] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [P01DA017259] Funding Source: NIH RePORTER
- NCI NIH HHS [R33 CA118696-02, CA 087660, R33 CA118696, R01 CA087660, R01 CA087660-08, CA 118696] Funding Source: Medline
- NIDA NIH HHS [DA 017259, P01 DA017259, P01 DA017259-05] Funding Source: Medline
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Genome sequencing projects have provided researchers with a complete inventory of the predicted proteins produced by eukaryotic and prokaryotic organisms. Assignment of functions to these proteins represents one of the principal challenges for the field of proteomics. Activity-based protein profiling (ABPP) has emerged as a powerful chemical proteomic strategy to characterize enzyme function directly in native biological systems on a global scale. Here, we review the basic technology of AMP, the enzyme classes addressable by this method, and the biological discoveries attributable to its application.
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