Pentoxifylline and vitamin E combination for superficial radiation-induced fibrosis: A phase II clinical trial

We treated 34 radiation-induced superficial fibrotic lesions with pentoxifylline and vitamin E for 3 months. Mean surface area of the lesions decreased from 112 to 65 cm(2) after treatment (P < 0.001). A subgroup of 21 fibrotic lesions received the medications for 6 months, in which surface area decreased from 80 to 27 cm(2) (p < 0.001). Pentoxifylline-vitamin E combination improved radiation-induced fibrosis. (c) 2005 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 77 (2005) 324-326.