Journal
ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 6
Volume 6, Issue -, Pages 427-453Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.anchem.111808.073648
Keywords
microdialysis; biosensor; human; brain; tissue; electrode
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Funding
- Engineering and Physical Sciences Research Council [EP/K503381/1] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council Funding Source: Medline
- Wellcome Trust [094912] Funding Source: Medline
- Department of Health Funding Source: Medline
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Continuous monitoring of clinical biomarkers offers the exciting possibility of new therapies that use biomarker levels to guide treatment in real time. This review explores recent progress toward this goal. We initially consider measurements in body fluids by a range of analytical methods. We then discuss direct tissue measurements performed by implanted sensors; sampling techniques, including microdialysis and ultrafiltration; and noninvasive methods. A future directions section considers analytical methods at the cusp of clinical use.
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