Journal
ANNUAL REVIEW OF ANALYTICAL CHEMISTRY
Volume 1, Issue -, Pages 423-449Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.anchem.1.031207.113042
Keywords
microenvironment; extracellular matrix; microfabrication
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Funding
- University of Wisconsin, Madison MMB laboratory
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Microfluidic technology holds great promise for the creation of advanced cell culture models. In this review, we discuss the characterization of cell cult-Lire in microfluidic systems, describe important biochemical and physical features of the cell microenvironment, and review studies of microfluidic cell manipulation in the context of these features. Finally, we consider the integration of analytical elements, ways to achieve high throughput, and the design constraints imposed by cell biology applications.
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