Journal
ANNUAL REVIEW OF ANALYTICAL CHEMISTRY
Volume 1, Issue -, Pages 451-483Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.anchem.1.031207.113053
Keywords
neuropeptides; hormones; cytokines; mass spectrometric imaging; single-cell measurements; quantitation
Categories
Funding
- National Science Foundation [CHE-05-26692, CHE-0449991]
- National Institute on Drug Abuse [P30 DA 018310]
- National Institutes of Health [1R01DK071801]
- Alfred R Sloan Research Fellowship
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK071801] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [P30DA018310] Funding Source: NIH RePORTER
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The function and activity of almost every circuit in the human brain are modified by the signaling peptides (SPs) surrounding the neurons. As the complement of peptides an vary even in adjacent neurons and their physiological actions can occur over a broad range of concentrations, the required figures of merit for techniques to characterize SPs are Surprisingly stringent. In this review, we describe the formation and catabolism of SPs and highlight a range of miss spectrometric techniques used to characterize SPs. Approaches that supply high chemical information content, direct tissue profiling, spatially resolved data, and temporal information on peptide release are also described. Because of advances in measurement technologies, Our knowledge of SPs has greatly increased over the last decade, and SP discoveries will Continue as the, capabilities of modern measurement approaches improve.
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