Journal
FITOTERAPIA
Volume 76, Issue 7-8, Pages 722-724Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2005.07.008
Keywords
Crocus sativus; safranal; crocin; anticonvulsant
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The anticonvulsant activities of Crocus sativus stigma constituents, safranal and crocin, were evaluated in mice using pentylenetetrazole (PTZ)-induced convulsions in mice. Safranal (0.15 and 0.35 ml/kg, i.p.) reduced the seizure duration, delayed the onset of tonic convulsions and protected mice from death. Crocin (200 mg/kg, i.p.) did not show anticonvulsant activity. (c) 2005 Elsevier B.V. All rights reserved.
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