Journal
EUROPEAN NEUROPSYCHOPHARMACOLOGY
Volume 15, Issue 6, Pages 625-632Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.euroneuro.2005.03.004
Keywords
nicotine; nucleus accumbens; microdialysis; conditioned place preference
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The action of nicotine on the nicotinic receptor-mediated release of inhibitory and excitatory acids in the nucleus accumbens, NAC, of freely moving rats was studied in order to clarify their effects' on reinforcing behavior as estimated by conditioned place preference (CPP). Using the technique of microdialysis, intraperitoneal (i.p.) injections of nicotine (0.15-0.3-0.6 mg/kg), significantly increased aspartate, glutamate, arginine, taurine, and alanine microdialysate content in the nucleus accumbens. The same doses of nicotine were able to elicit a reinforcing effect in a CPP paradigm which was probably associated with the increased brain levels of excitatory acids triggering additional dopamine release in the mesolimbic system. (c) 2005 Elsevier B.V and ECNP. All rights reserved.
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