Journal
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
Volume 4, Issue 6, Pages 603-613Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/153303460500400604
Keywords
biodegradable device; cancer; gold/dendrimer nanocomposite; guest-host nanodevices; imaging; nanoparticle; radiation therapy; and toxicity
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Funding
- NCI NIH HHS [R01-CA-104479-01] Funding Source: Medline
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Our results indicate that the surface chemistry, composition, and 3-D structure of nanoparticles are critical in determining their in vivo biodistribution, and therefore the efficacy of nanodevice imaging and therapies. We demonstrate that gold/dendrimer nanocomposites in vivo, present biodistribution characteristics different from PAMAM dendrimers in a B16 mouse tumor model system. We review important chemical and biologic uses of these nanodevices and discuss the potential of nanocomposite devices to greatly improve cancer imaging and therapy, in particular radiation therapy. We also discuss major issues confronting the use of nanoparticles in the near future, with consideration of toxicity analysis and whether biodegradable devices are needed or even desirable.
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