Journal
JOURNAL OF IMMUNOLOGY
Volume 175, Issue 11, Pages 7504-7511Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.175.11.7504
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Funding
- NIAID NIH HHS [AI053075, R01 AI053075-02, R01 AI053075-04, R01 AI053075-05, R01 AI053075-03, R01 AI053075] Funding Source: Medline
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Although the antibacterial effects of Abs are well studied in in vitro systems, the in vivo effects of Abs cannot always be accurately predicted. Complicated cross-talk between different effector functions of Abs and various arms of the immune system can affect their activities in vivo. Using the mouse respiratory pathogen Bordetella bronchiseptica, we examined the mechanisms of Ab-mediated clearance of bacteria from the respiratory tract. Interestingly, although TLR4 was not necessary for protective immunity following infection, it was required for rapid bacterial clearance in mice that were vaccinated or adoptively transferred Abs. TLR4 was important for the rapid recruitment of neutrophils that are necessary for Ab-mediated bacterial clearance via a mechanism that requires both Fc gamma R and CR3. These data are consistent with a model in which TLR4-mediated inflammatory responses aid in the recruitment of neutrophils, which phagocytose Ab- and complement-opsonized bacteria via FcR gamma s and CR3. Although pattern recognition receptors are known to be involved in innate immunity and the generation of adaptive immunity, their contributions to specific adaptive immune functions should be considered in ongoing efforts to improve vaccine-induced protective immunity.
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