Journal
ARCHIV DER PHARMAZIE
Volume 338, Issue 12, Pages 605-608Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.200500132
Keywords
Sonogashira reaction; mitsunobu reaction; macrolactones
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Polyketide-derived macrolactones like zearalenone (1), zearalane (2) or curvularin (3) display a wide range of interesting pharmacological activities. Here, we present a short and efficient approach towards this class of natural products by a combination of the Sonogashira and Mitsunobu reactions. The resulting lactone 9 was tested against human cancer cell lines at the NCl.
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