Journal
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Volume 76, Issue 12, Pages 1730-1732Publisher
B M J PUBLISHING GROUP
DOI: 10.1136/jnnp.2005.063750
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This study examined the efficacy of lamotrigine in the prevention of migraine aura. Fifty nine patients suffering from migraine with aura received lamotrigine in a controlled three year prospective open study. Treatment response was defined as a reduction of aura frequency each month by at least 50%. Primary endpoint was reached by three quarters of the patients. Lamotrigine significantly reduced both frequency of migraine aura ( mean, 1.5 (SD, 0.6) each month before v 0.4 (0.7) after treatment; p< 0.001) and aura duration ( mean, 27 ( SD, 11) minutes before v 8 ( 14) after treatment; p< 0.001). Furthermore, more than three quarters of those patients with a reduction of aura symptoms experienced a significant reduction of frequency of migraine attacks ( mean, 2.1 ( SD, 1.0) each month before v 1.2 (1.1) after treatment; p< 0.001). Lamotrigine was highly effective in reducing migraine aura and migraine attacks. The strong correlation between reduction of aura symptoms and migraine attacks stresses the potential role of aura-like events and possibly cortical spreading depression as a trigger for trigeminal vascular activation, and subsequently the development of migraine headaches.
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