Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 62, Issue 24, Pages 2985-3001Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-005-5181-5
Keywords
TRP; TRPV; mechano-TRP; osmo-TRP; C. elegans; Drosophila; TRPV4; OSM-9; OCR-2; NAN; IAV
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Funding
- NIMH NIH HHS [K08 MH64702] Funding Source: Medline
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Transient receptor potential (TRP) ion channels have been identified as cellular sensors responding to diverse external and internal stimuli. This review will cover the TRPV subfamily that comprises vertebrate and invertebrate members. The six mammalian TRPV channels were demonstrated to function in thermosensation, mechanosensation, osmosensation and Ca2+ uptake. Invertebrate TRPV channels, five in Caenorhabditis elegans and two in Drosophila, have been shown to play a role in mechanosensation, such as hearing and proprioception in Drosophila and nose touch in C. elegans, and in the response to osmotic and chemical stimuli in C. elegans. We will focus here on the role that TRPV ion channels play in mechanosensation and a related sensory (sub-)modality, osmosensation.
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