Journal
ANNALS OF NEUROLOGY
Volume 58, Issue 6, Pages 821-828Publisher
WILEY
DOI: 10.1002/ana.20662
Keywords
-
Categories
Funding
- NINDS NIH HHS [1U01 NS 40069-01A2] Funding Source: Medline
Ask authors/readers for more resources
Hypotheses that inflammation contributes to neonatal cerebral white matter damage have evolved over the last three decades. The latest, expanded here, suggests that the adaptive immune system contributes to the intensity and duration of the processes that result in damage to cerebral white matter in the fetus and newborn. We propose several mechanisms by which fetal T lymphocytes could be activated during fetal exposure to infection. These include specific recognition of bacterial antigens, specific recognition of autoantigens, polyclonal activation by Toll-like receptors, and bystander activation by cytokines.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available