Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 49, Issue 12, Pages 5160-5161Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.49.12.5160-5161.2005
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- NIAID NIH HHS [AI35707, P01 AI035707] Funding Source: Medline
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Cruzain is an essential cysteine protease of Trypanosoma cruzi and a therapeutic target for Chagas' disease. Eight dogs were infected with T. cruzi; three were treated with an inhibitor of cruzain, K777, for 14 days. Treatment with K777 abrogated myocardial damage by T. cruzi, as documented by histopathological lesion scores and serum troponin I levels.
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