Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 169, Issue 1-2, Pages 86-96Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2005.08.012
Keywords
inflammation; TRPV1; neuropeptides; transgenic/knockout; skin
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Funding
- Wellcome Trust Funding Source: Medline
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The purpose of this study was to examine the involvement of the transient receptor potential vanilloid receptor 1 (TRPV1) in inflammatory processes observed in murine allergic contact dermatitis (ACD). Oxazolone-induced ACD evoked a significant ear swelling after 24-72 h. It was augmented in TRPV1 knockout mice at all time points and supported by histological analysis and measure of TNF-alpha. However, tissue swelling and cytokine generation was significantly reduced in both neurokinin I receptor and calcitonin gene-related peptide (CGRP) knockout mice. A protective involvement of the TRPV1 receptor was identified of contact dermatitis distinct from mechanisms involving the major pro-inflammatory neuropeptides. (C) 2005 Elsevier B.V. All rights reserved.
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