Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 33, Issue -, Pages 1282-1284Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0331282
Keywords
ADP-ribosylation factor-GTPase-activating protein (Arf-GAP); Arf-GAP containing Src homology domain; ankyrin repeats; and pleckstrin homology domains 1 (ASAP1); cancer; centaurin beta 4; development and differentiation-enhancing factor 1 (DDEF1); metastasis
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Centaurin beta 4 proteins are products of the DDEF1 (development and differentiation-enhancing factor 1) locus on human chromosome 8q24.1-24.2. Recent reports have indicated that this region and its products are amplified during development of several human cancers. Centaurins are GAPS (GTPase-activating proteins) that, together with GEFs (guanine nucleotide-exchange factors), regulate cyclic activation of Arfs (ADP-ribosylation factors), members of the Ras GTPase superfamily. Centaurin beta 4 proteins associate with a variety of cellular signalling components implicated in control of growth, survival and movement and may act to direct assembly and/or disassembly of molecular complexes in concert with Arf, lipid and protein phosphorylation signalling pathways.
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