Journal
NATURE METHODS
Volume 2, Issue 12, Pages 955-957Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH811
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Funding
- Biotechnology and Biological Sciences Research Council [S19816] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [S19816] Funding Source: Medline
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Bottom-up proteomics is the analysis of peptides derived from single proteins or protein mixtures, and because each protein generates tens of peptides, there is scope for controlled reduction in complexity. We report here a new strategy for selective isolation of the N-terminal peptides of a protein mixture, yielding positionally defined peptides. The method is tolerant of several fragmentation methods, and the databases that must be searched are substantially less complex.
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