Journal
DIABETES
Volume 54, Issue -, Pages S4-S10Publisher
AMER DIABETES ASSOC
DOI: 10.2337/diabetes.54.suppl_2.S4
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- PHS HHS [DDK51705] Funding Source: Medline
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This presentation is an overview of mechanisms for developing and maintaining self-tolerance in mammalian organisms. Because this meeting is focused on type 1 diabetes and its mechanisms, the discussion deals primarily with mechanisms of T-cell tolerance, since type 1 diabetes in both effector and initiator phases is primarily a T-cell-mediated autoimmune disease. Emphasis is placed' on more recently discovered mechanisms of maintaining self-tolerance (autoimmune regulator [AIRE]) and a new defect in T-cell negative selection. The emerging picture is that of a polygenic disease with various combinations of different alleles of many genes with important roles in the normal immune response or normal immune responses.
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