Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 20, Issue 12, Pages 2224-2232Publisher
WILEY
DOI: 10.1359/JBMR.050803
Keywords
estrogen; testosterone; human CD14(+) monocytes; osteoclast formation; bone resorption; estrogen receptor; androgen receptor
Categories
Ask authors/readers for more resources
Using human peripheral blood CD14(+) osteoclast precursors, we show that testosterone directly inhibits osteoclast formation and bone resorption at physiological concentrations. Instead, estrogen has no direct effects, whereas its action seems to be mediated through osteoblasts by producing osteoprotegerin. Both estrogen and testosterone acts through their cognate receptors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available