Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 16, Issue 6, Pages 655-662Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2005.06.003
Keywords
neural crest cells; epithelial-mesenchymal transition (EMT); cell cycle; cell survival; transcription factors
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The development of the neural crest up to the stage where they leave the neural tube can be observed as a series of concatenated but independent events that involve dorsalization of the neural plate/neural tube, neural crest induction, segregation and stabilization, epithelial to mesenchymal transition and delamination. During all these processes, the nascent neural crest cells are subjected to the influence of different signals and have to overcome competition for cell fate and apoptotic signals. In addition, striking rostrocaudal differences unveil how the regulatory cascades are somehow different but still can lead to the production of bona fide neural crest cells. (c) 2005 Elsevier Ltd. All rights reserved.
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