Journal
ANNALS OF TROPICAL PAEDIATRICS
Volume 30, Issue 3, Pages 213-218Publisher
MANEY PUBLISHING
DOI: 10.1179/146532810X12786388978607
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Funding
- Commission on Higher Education
- Thailand Research Fund [RMU 4890019]
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Background: Evidence of hepatocellular damage is common in dengue-infected individuals. Hepatocyte growth factor (HGF), a key cytokine responsible for liver regeneration, may play a prognostic role in dengue virus infection. Aim: To determine the relationship between serum HGF level and disease severity in patients with dengue virus infection. Methods: Serum samples from 27 children [17 dengue fever (DF), ten dengue haemorrhagic fever (DHF)] with serologically confirmed dengue virus infection during the febrile, toxic stages and at follow-up were analysed for HGF. Serum samples obtained from nine healthy children served as the control group. Results: In dengue-infected patients, serum HGF was significantly higher at the febrile and toxic stages than at follow-up (p<0.05). In comparison with DF, patients with DHF had a greater level of HGF at the febrile stage (p<0.05). A cut-off HGF level of 1220 pg/mL obtained during the febrile stage showed a sensitivity of 90% and a specificity of 53% for predicting clinical progression to DHF (area under the ROC curve 0.75). Conclusion: Serum HGF level at the early stage of dengue virus infection is elevated and may be a useful predictor for clinical progression to DHF.
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