Journal
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
Volume 330, Issue 6, Pages 303-310Publisher
ELSEVIER SCIENCE INC
DOI: 10.1097/00000441-200512000-00008
Keywords
metabolic syndrome; hypertension; obesity; insulin resistance; dyslipidemia; microalbuminuria
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The cause of hypertension in the metabolic syndrome is complex and multifactorial and all of the elements of the metabolic syndrome, including obesity, insulin resistance, and the characteristic dyslipidemia probably are involved in mediating changes ultimately resulting in hypertension and modifying its course. Of these elements, obesity may play the most important and pivotal role in creating the conditions that lead to hypertension in the metabolic syndrome. This is not to say that the other elements of the syndrome are less important, and, as we gain more insight into the processes involved, we should be able to better manage the disease and tailor our therapeutic interventions appropriately.
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