Journal
JOURNAL OF ORGANOMETALLIC CHEMISTRY
Volume 690, Issue 24-25, Pages 5533-5540Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2005.06.010
Keywords
rhodium(II); carbenoid; diazoketone; carbonyl ylide; 1,3-dipole; dipolar-cycloaddition; tetrahydrofuran
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The transition metal catalyzed reaction of alpha-diazo carbonyl compounds has found numerous applications in organic synthesis, and its use in either heterocyclic or carbocyclic ring formation is well precedented. In contrast to other catalysts that are suitable for carbenoid reactions of diazo compounds, those constructed with the dirhodium(II) framework are most amenable to ligand modification that, in turn, can influence reaction selectivity. The reaction of rhodium carbenoids with carbonyl groups represents a very efficient method for generating carbonyl ylide dipoles. Rhodium-mediated carbenoid-carbonyl cyclization reactions have been extensively utilized as a powerful method for the construction of a variety of novel polycyclic ring systems. This article will emphasize some of the more recent synthetic applications of the tandem rhodium carbenoid cyclization/cycloaddition cascade for natural product synthesis. Discussion centers on the chemical behavior of the rhodium metal carbenoid complex that is often affected by the nature of the ligand groups attached to the metal center. (c) 2005 Elsevier B.V. All rights reserved.
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