Journal
CELL CYCLE
Volume 4, Issue 12, Pages 1749-1752Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.4.12.2224
Keywords
LOXL2; Snail; E-cadherin; EMT; GSK-3 beta
Categories
Ask authors/readers for more resources
Epithelial-mesenchymal transition (EMT) is considered as an essential determinant of carcinoma progression. The transcription factor Snail controls EMT by repressing E-cadherin gene expression and other epithelial genes. Snail protein stability and cellular localization is finely controlled by GSK3 beta-dependent phosphorylation and subsequent ubiquitination. GSK3 beta phosphorylates Snail at two different motifs which induce its nuclear export and association with beta-Trcp thus leading to Snail degradation. Recently, Snail was found to interact physical and functionally with LOXL2, a member of the lysyl oxidase gene family. Interestingly, LOXL2 seems to attenuate the GSK3 beta-dependent Snail degradation. Here, we discuss the relevance of this new potential mechanism of regulation and the role of LOXL2 during carcinoma progression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available