Journal
FITOTERAPIA
Volume 76, Issue 7-8, Pages 755-757Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2005.08.015
Keywords
Cybistax antisyphilitica; larvicidal activity; Aedes aegypti; lapachol
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The larvicidal activity against Aedes aegypti larvae of a stem wood hexane extract of Cybistax antisyphilitica was evaluated. Bioassay-guided fractionation of the crude extract, monitored by larvicidal assay, led to the isolation of a natural quinone identified as 2-hydroxy-3-(3-methyl-2-butenyl)-1.4-naphthoquinone (lapachol). This compound was quite potent against A. aegypti larvae (LC50 26.3 mu g/ml). (c) 2005 Elsevier B.V. All rights reserved.
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