Journal
JOURNAL OF ORGANOMETALLIC CHEMISTRY
Volume 690, Issue 24-25, Pages 5581-5590Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2005.07.042
Keywords
water-soluble Fischer carbene complex; bioorganometallics; PEGylation; protein labelling
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Syntheses of Fischer carbene complexes with various hydrophilic tethers (4, 6a, 6b, 6c, 8a, 8b, 14a, 14b, 15 and 19) are described. The water-soluble carbene complex, 14b, was used to label and pegylate bovine serum albumin (BSA) without affecting its conformation. The red complex, 19, underwent a sharp color change to yellow on reaction with BSA, a feature that is potentially useful for developing assay methods. (c) 2005 Elsevier B.V. All rights reserved.
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