Journal
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
Volume 270, Issue -, Pages 13-17Publisher
ELSEVIER
DOI: 10.1016/j.colsurfa.2005.05.031
Keywords
Alzheimer's disease; beta-amyloid; liposomes; kinetics; peptides
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The beta-amyloid peptide (A beta) is the primary constituent of senile plaques, a defining feature of Alzheimer's disease. A beta presumably exerts its neurotoxic action through an interaction with neuronal membranes. We have studied the effect of neutral liposomes (average diameter approximate to 200 nm) on the kinetics of A beta fibrillogenesis, and on the binding of fibrillar peptide to the dye Congo Red. Our results indicate that neutral liposomes increase the time of A beta autoaggregation in a concentration-dependent manner. This delay is mainly due a reduction of the nucleation constant. In addition, binding studies reveal that the amount of fibrillar A beta, as well as the concentration of binding sites, decreases in the presence of liposomes. Our findings suggest that A beta partially penetrates the lipid membrane. (c) 2005 Elsevier B.V. All rights reserved.
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