Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume 26, Issue 6, Pages 427-441Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijantimicag.2005.09.006
Keywords
antifungal agents; drug designs molecular modelling; three-dimensional characterisation; X-ray crystallography
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The alarming, rise in life-threatening systemic fungal infections due to the emergence of drug-resistant fungal strains had produced all increased demand for new antimycotics, especially those targeting novel antifungal Structures. Drug discovery has developed from screening natural products and chemical synthesis to a modern approach, namely structure-based drug design. Whilst many antifungal agents currently ill use were discovered more than 30 years ago, characterisation of various drug targets has only been achieved recently, contributing immensely to understanding the structure-activity relationships of antifungals and their targets. Three-dimensional characterisation has become a well established tool for modern antifungal drug research and should play all important role in investigations for new antifungal agents. (c) 2005 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
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